Neuroendocrine cell differentiation

Across TCGA patient cohorts, RNA activity of the Neuroendocrine cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD4, DOCK8, and GNAI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroendocrine cell differentiation activity versus CD4 in CCRCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CD4 →	-0.464	-0.075	<.001	.003	3	5
HNSC	DOCK8 →	-0.305	-0.061	.001	.009	3	5
HNSC	GNAI1 →	+0.344	+0.055	.003	.003	3	5
LUAD	BMP2K_S728 →	-0.572	-0.080	<.001	.002	3	5
LUAD	LGALS9 →	-0.321	-0.061	.002	.004	3	5
HNSC	ARHGAP30 →	-0.392	-0.065	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061101 vs CD4 — CCRCC

Explore this scatter interactively →