Positive regulation of myeloid leukocyte cytokine production involved in immune response

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid leukocyte cytokine production involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM1, TNFAIP3, and THEMIS2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid leukocyte cytokine production involved in immune response activity versus PRDM1 in THYM (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PRDM1 →	+1.396	+0.051	<.001	<.001	3	32
MESO	TNFAIP3 →	+1.735	+0.044	<.001	<.001	3	31
ACC	THEMIS2 →	+2.047	+0.048	<.001	<.001	3	31
LAML	TLR4 →	+2.064	+0.079	<.001	<.001	3	31
LAML	TNFRSF1B →	+2.081	+0.086	<.001	<.001	3	31
SARC	PIK3R5 →	+1.358	+0.054	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061081 vs PRDM1 — THYM

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