Negative regulation of cell growth involved in cardiac muscle cell development

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXP1, MIR199A1, and RGS2, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell growth involved in cardiac muscle cell development activity versus FOXP1 in UCS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	FOXP1 →	+0.836	+0.046	<.001	.007	1	23
CHOL	MIR199A1 →	-0.630	-0.062	.004	<.001	2	22
MESO	RGS2 →	+1.760	+0.062	<.001	<.001	2	17
LAML	PPARA →	+0.499	+0.068	<.001	<.001	3	15
UCS	SOBP →	+1.441	+0.049	.001	.001	3	15
LGG	RASGRF2 →	+0.866	+0.039	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061052 vs FOXP1 — UCS

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