Negative regulation of wound healing

Across TCGA patient cohorts, RNA activity of the Negative regulation of wound healing pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, PALM2AKAP2, and PDLIM4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of wound healing activity versus VCL in COAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VCL →	+0.656	+0.042	<.001	<.001	3	10
UCEC	PALM2AKAP2 →	+0.496	+0.066	<.001	<.001	3	9
COAD	PDLIM4 →	+0.721	+0.047	<.001	<.001	3	9
COAD	RSU1 →	+0.586	+0.044	<.001	<.001	3	9
CCRCC	SERPINA3 →	+0.610	+0.047	.001	<.001	3	9
OV	SERPINF1 →	+0.756	+0.039	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061045 vs VCL — COAD

Explore this scatter interactively →