Negative regulation of wound healing

Across TCGA cell cohorts, RNA activity of the Negative regulation of wound healing pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC11A1, RBM4B, and CGRRF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC11A1 grouped by Negative regulation of wound healing-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC11A1 →	+0.226	+0.708	.004	.005	3	5
OVARY	RBM4B →	+0.630	+0.938	<.001	.002	3	4
BONE	CGRRF1 →	-1.034	-0.932	.006	.008	3	4
BONE	CHN2 →	+2.908	+1.328	.009	.002	3	4
BONE	CBX2 →	+2.035	+1.587	.008	<.001	3	4
CNS	HEXD →	+0.648	+0.883	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC11A1 by Negative regulation of wound healing activity — PANCREAS

Explore this box plot interactively →