Negative regulation of vascular wound healing

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR200B, SLC12A2, and TNF, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIR200B grouped by Negative regulation of vascular wound healing-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MIR200B →	-0.731	-2.025	<.001	<.001	3	8
BREAST	SLC12A2 →	-0.366	-0.985	<.001	<.001	3	7
CNS	TNF →	-0.245	-1.070	<.001	.001	3	6
KIDNEY	RABL2A →	-0.320	-1.181	<.001	.001	3	5
OVARY	HRH3 →	-0.373	-1.101	.003	<.001	3	5
LUNG_NSCLC_LUAD	SERPINE1 →	-0.100	-0.786	.002	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIR200B by Negative regulation of vascular wound healing activity — LIVER

Explore this box plot interactively →