Negative regulation of vascular wound healing

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of vascular wound healing pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH, show the opposite pattern, with lower activity in tumor tissue.

THCA, KIRC, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	IV	+0.146	<.001	11	view →
KIRC	Male	II,III,IV	+0.109	<.001	11	view →
COAD	Female	All	+0.088	<.001	10	view →
READ	All	All	+0.063	.029	3	view →
CHOL	All	All	+0.093	.005	2	view →
BLCA	All	III,IV	+0.059	.009	2	view →
BRCA	All	All	+0.027	.004	2	view →
HNSC	All	All	+0.026	.025	2	view →
KICH	Female	III,IV	−0.073	.016	1	view →
STAD	All	All	+0.041	.024	1	view →
KIRP	All	All	+0.024	.049	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0061044–THCA

Open the THCA breakdown →