Negative regulation of vascular wound healing

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular wound healing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC15, PAX9, and ZFP69B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AC15 grouped by Negative regulation of vascular wound healing-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	H2AC15 →	+0.782	+0.820	<.001	.003	3	5
LUNG_SCLC	PAX9 →	+2.007	+0.890	.006	.007	3	3
SKIN	ZFP69B →	+0.853	+1.267	.003	<.001	3	3
CNS	ACAA1 →	-0.599	-0.956	.004	.001	3	3
SKIN	AP3D1 →	-0.576	-1.191	<.001	<.001	3	3
LIVER	MMP24OS →	+1.759	+1.551	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AC15 by Negative regulation of vascular wound healing activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →