Regulation of vascular wound healing

Across TCGA cell cohorts, RNA activity of the Regulation of vascular wound healing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYP, FGF9, and TUSC3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vascular wound healing activity versus SYP in CNS (Pearson r = 0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SYP →	+1.548	+1.996	.009	.008	2	1
CNS	FGF9 →	+0.766	+1.996	.009	.008	2	1
CNS	TUSC3 →	+5.566	+1.996	.007	.008	2	1
CNS	TUBB4A →	+0.680	+1.996	.007	.008	2	1
CNS	KLC3 →	+0.758	+1.996	.002	.008	2	1
CNS	FGF21 →	+0.231	+1.996	.008	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061043 vs SYP — CNS

Explore this scatter interactively →