Uterus morphogenesis

Across TCGA patient cohorts, RNA activity of the Uterus morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00498, IL6, and ZNF740, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Uterus morphogenesis activity versus LINC00498 in BRCA (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC00498 →	+0.326	+0.435	.002	.004	3	5
LSCC	IL6 →	-1.184	-0.633	.001	.008	3	5
LSCC	ZNF740 →	+0.414	+0.637	<.001	.007	3	5
LSCC	UPP1 →	-0.848	-0.710	.001	.003	3	5
UCEC	TET1 →	+0.501	+0.747	<.001	<.001	3	4
OV	MT2A →	-0.906	-0.816	.004	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061038 vs LINC00498 — BRCA

Explore this scatter interactively →