Regulation of cartilage development

Across TCGA patient cohorts, RNA activity of the Regulation of cartilage development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCUBE2, GLI3, and AK5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cartilage development activity versus SCUBE2 in BRCA (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCUBE2 →	+2.420	+0.372	<.001	<.001	3	8
BRCA	GLI3 →	+0.822	+0.357	<.001	<.001	3	7
PDAC	AK5 →	+0.533	+0.649	<.001	<.001	3	7
PDAC	FAT3 →	+0.594	+0.556	<.001	<.001	3	7
PDAC	ZFPM2 →	+0.613	+0.577	<.001	<.001	3	7
COAD	JAM2 →	+0.640	+0.435	.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061035 vs SCUBE2 — BRCA

Explore this scatter interactively →