Eyelid development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Eyelid development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LATS1, RBFOX2, and AMOTL1, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eyelid development in camera-type eye activity versus LATS1 in TGCT (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	LATS1 →	+0.721	+0.097	<.001	<.001	3	24
THYM	RBFOX2 →	+1.202	+0.069	<.001	<.001	3	23
MESO	AMOTL1 →	+1.230	+0.080	<.001	<.001	3	23
MESO	INHBA →	+1.922	+0.081	<.001	<.001	3	22
THYM	AGO3 →	+0.549	+0.067	<.001	<.001	3	22
THYM	MAP4K5 →	+1.022	+0.076	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061029 vs LATS1 — TGCT

Explore this scatter interactively →