Eyelid development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Eyelid development in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTK7, COL5A2, and CEP170_S379, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eyelid development in camera-type eye activity versus PTK7 in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTK7 →	+0.506	+0.050	.002	<.001	3	6
BRCA	COL5A2 →	+0.511	+0.045	.004	<.001	3	6
GBM	CEP170_S379 →	+0.481	+0.082	<.001	<.001	3	6
LUAD	RGS10 →	-0.459	-0.090	<.001	<.001	3	5
BRCA	EGFR →	+0.453	+0.037	<.001	<.001	3	5
OV	SEC23A →	+0.214	+0.045	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061029 vs PTK7 — BRCA

Explore this scatter interactively →