Eyelid development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Eyelid development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF8, CAMK1, and PAG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eyelid development in camera-type eye activity versus KLF8 in LSCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KLF8 →	+0.555	+0.145	.002	.004	2	5
LUAD	CAMK1 →	+0.289	+0.225	.004	.004	3	4
BRCA	PAG1 →	+0.464	+0.529	.001	.006	3	4
BRCA	VCAM1 →	+0.938	+0.775	<.001	<.001	3	4
CCRCC	SNTA1 →	+0.611	+0.343	.003	.005	3	3
CCRCC	STAG2 →	+0.170	+0.236	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061029 vs KLF8 — LSCC

Explore this scatter interactively →