Eyelid development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Eyelid development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUN1, HACD1, and MICAL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eyelid development in camera-type eye activity versus SUN1 in OVARY (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SUN1 →	+0.924	+1.973	.004	<.001	3	4
LUNG_SCLC	HACD1 →	-3.186	-1.711	.005	<.001	3	3
LUNG_SCLC	MICAL3 →	+1.102	+1.728	.001	<.001	2	4
UPPER_AERODIGESTIVE_TRACT	FAM214B →	+2.150	+1.467	<.001	.003	3	3
OVARY	HHLA2 →	+0.205	+1.596	.001	.002	3	3
OVARY	DIPK1B →	+1.972	+1.707	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061029 vs SUN1 — OVARY

Explore this scatter interactively →