Establishment of endothelial barrier

Across TCGA patient cohorts, RNA activity of the Establishment of endothelial barrier pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLPX, PALM, and TNS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of endothelial barrier activity versus CLPX in LSCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLPX →	-0.309	-0.058	<.001	<.001	3	9
UCEC	PALM →	+0.665	+0.069	<.001	.001	3	9
CCRCC	TNS2 →	+0.417	+0.064	<.001	<.001	3	9
CCRCC	SORBS1 →	+0.695	+0.060	<.001	.002	3	8
GBM	SUSD2 →	+0.550	+0.043	<.001	<.001	3	8
PDAC	USP10 →	-0.186	-0.028	.006	.006	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061028 vs CLPX — LSCC

Explore this scatter interactively →