Establishment of endothelial barrier

Across TCGA cell cohorts, RNA activity of the Establishment of endothelial barrier pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRB3, LRG1, and CD2AP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of endothelial barrier activity versus CRB3 in LIVER (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CRB3 →	+3.974	+0.497	.004	.002	3	5
LIVER	LRG1 →	+3.354	+0.466	.005	.005	3	5
PANCREAS	CD2AP →	+1.231	+0.444	<.001	<.001	3	5
LUNG_NSCLC_LUAD	ICAM1 →	+2.852	+0.302	.001	<.001	3	4
OVARY	GPRC5B →	+2.183	+0.292	<.001	<.001	3	4
STOMACH	CRIPT →	+0.541	+0.301	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061028 vs CRB3 — LIVER

Explore this scatter interactively →