Cardiac muscle tissue regeneration

Across TCGA patient cohorts, RNA activity of the Cardiac muscle tissue regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A11, UGP2_S13, and YTHDF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle tissue regeneration activity versus S100A11 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A11 →	+0.630	+0.081	.003	.003	3	6
LUAD	UGP2_S13 →	+0.565	+0.092	<.001	<.001	3	5
PDAC	YTHDF2 →	-0.138	-0.059	.005	.002	3	5
PDAC	F13A1 →	+0.406	+0.057	<.001	<.001	3	5
OV	C1S →	+0.451	+0.074	.003	.001	3	5
OV	LRP1 →	+0.515	+0.081	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061026 vs S100A11 — GBM

Explore this scatter interactively →