Membrane fusion

Across TCGA patient cohorts, RNA activity of the Membrane fusion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR36, NOC4L, and SNTB2_S222, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane fusion activity versus WDR36 in LSCC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR36 →	-0.313	-0.030	<.001	<.001	3	9
LSCC	NOC4L →	-0.255	-0.026	<.001	<.001	3	8
LSCC	SNTB2_S222 →	+0.633	+0.035	<.001	<.001	3	7
LSCC	SRPK1_S311 →	-0.578	-0.037	<.001	<.001	3	7
LSCC	RPL10A →	-0.161	-0.030	.002	.003	3	7
GBM	RRP9 →	-0.431	-0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061025 vs WDR36 — LSCC

Explore this scatter interactively →