Membrane fusion

Across TCGA cell cohorts, RNA activity of the Membrane fusion pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC6, LRRK2, and TUBG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AC6 grouped by Membrane fusion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	H2AC6 →	-0.248	-0.178	<.001	<.001	3	4
OESOPHAGUS	LRRK2 →	-0.127	-0.159	.007	.002	3	3
OESOPHAGUS	TUBG2 →	-0.196	-0.161	.001	<.001	3	3
BREAST	IRX4 →	+0.070	+0.124	.001	.007	3	3
BREAST	ADCY3 →	-0.101	-0.120	.005	.003	3	3
BLOOD_Myeloma	ELP3 →	+0.404	+0.272	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AC6 by Membrane fusion activity — OESOPHAGUS

Explore this box plot interactively →