Regulation of mRNA catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of mRNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL7, NDEL1_S198, and RPL11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA catabolic process activity versus RPL7 in HNSC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL7 →	-0.278	-0.082	<.001	<.001	3	5
HNSC	NDEL1_S198 →	-0.827	-0.106	<.001	.008	3	5
LSCC	RPL11 →	-0.121	-0.021	.006	.009	3	4
LUAD	RPS3A →	-0.180	-0.031	.001	<.001	3	4
UCEC	SELPLG_S358 →	+1.293	+0.051	<.001	<.001	3	4
LUAD	STAG2 →	+0.211	+0.029	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061013 vs RPL7 — HNSC

Explore this scatter interactively →