Hepaticobiliary system development

Across TCGA patient cohorts, RNA activity of the Hepaticobiliary system development pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTUD4, TASOR2, and MED13, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepaticobiliary system development activity versus OTUD4 in THYM (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	OTUD4 →	+1.206	+0.036	<.001	<.001	3	32
ACC	TASOR2 →	+1.154	+0.025	<.001	<.001	2	32
UVM	MED13 →	+1.082	+0.018	<.001	<.001	3	31
UVM	FNBP4 →	+1.066	+0.015	<.001	<.001	3	31
UVM	PIK3C2A →	+1.665	+0.015	<.001	<.001	3	31
UVM	SF3B1 →	+1.264	+0.018	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061008 vs OTUD4 — THYM

Explore this scatter interactively →