Hepaticobiliary system development

Across TCGA patient cohorts, RNA activity of the Hepaticobiliary system development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCL11A_S630, PRKCD, and MAP1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepaticobiliary system development activity versus BCL11A_S630 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BCL11A_S630 →	+1.093	+0.047	<.001	.006	3	5
OV	PRKCD →	-0.410	-0.041	.005	<.001	3	5
BRCA	MAP1A →	+0.308	+0.022	<.001	<.001	3	5
LSCC	ORC4 →	+0.257	+0.034	<.001	<.001	3	5
LSCC	MAP1B_S1779 →	+1.243	+0.032	<.001	<.001	3	5
LSCC	GNG7 →	-0.396	-0.038	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061008 vs BCL11A_S630 — HNSC

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