Hepaticobiliary system development

Across TCGA patient cohorts, RNA activity of the Hepaticobiliary system development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHCY, ACAD10, and CCDC57, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepaticobiliary system development activity versus AHCY in UCEC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AHCY →	+1.583	+0.210	.003	.008	3	3
UCEC	ACAD10 →	+0.546	+0.244	.003	<.001	3	3
UCEC	CCDC57 →	+0.597	+0.213	.005	.006	3	3
UCEC	PHLDB3 →	+0.523	+0.162	.006	.008	3	3
UCEC	RN7SKP71 →	-1.257	-0.183	<.001	.002	3	3
UCEC	RN7SKP80 →	-2.018	-0.203	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061008 vs AHCY — UCEC

Explore this scatter interactively →