Hepaticobiliary system development

Across TCGA cell cohorts, RNA activity of the Hepaticobiliary system development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D8B, KHDRBS3, and SCMH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D8B grouped by Hepaticobiliary system development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TBC1D8B →	+0.936	+0.201	.001	<.001	3	4
BONE	KHDRBS3 →	+3.557	+0.368	.006	.002	3	4
BLOOD_Myeloma	SCMH1 →	-0.822	-0.331	.006	<.001	3	4
OESOPHAGUS	H2BC4 →	-1.196	-0.168	.009	<.001	3	3
SKIN	GARS1 →	+0.699	+0.150	<.001	.001	3	3
LIVER	GKN1 →	-0.112	-0.187	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D8B by Hepaticobiliary system development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →