Hepaticobiliary system development

Across TCGA cell cohorts, RNA activity of the Hepaticobiliary system development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIPAL1, CGAS, and CCPG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepaticobiliary system development activity versus NIPAL1 in LIVER (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NIPAL1 →	-1.270	-0.383	.004	.008	3	5
CNS	CGAS →	+1.504	+0.210	.002	<.001	3	5
STOMACH	CCPG1 →	+1.571	+0.330	<.001	.002	3	4
BLOOD_Myeloma	PPP1R3E →	+1.532	+0.267	.001	.001	3	4
URINARY_TRACT	HMGN4 →	+1.195	+0.304	<.001	<.001	3	4
STOMACH	FSD1 →	-3.098	-0.278	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061008 vs NIPAL1 — LIVER

Explore this scatter interactively →