Positive regulation of dendritic spine morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic spine morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIAM1, NSMCE1-DT, and PRKCE, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine morphogenesis activity versus TIAM1 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TIAM1 →	+0.599	+0.390	<.001	.001	3	3
PDAC	NSMCE1-DT →	+0.290	+0.723	<.001	<.001	3	3
CCRCC	PRKCE →	-0.333	-0.625	.009	.002	3	3
CCRCC	CSNK1A1L →	-0.139	-0.443	.003	.008	3	3
OV	LINC02078 →	-0.025	-0.424	.001	.007	3	3
COAD	BANK1 →	-0.390	-0.607	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061003 vs TIAM1 — GBM

Explore this scatter interactively →