Positive regulation of dendritic spine morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic spine morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2H4, TLCD3B, and NIPSNAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine morphogenesis activity versus GTF2H4 in BLOOD_Leukemia (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GTF2H4 →	+0.452	+0.407	<.001	.001	3	4
BLOOD_Leukemia	TLCD3B →	+1.806	+0.493	<.001	.002	3	4
BLOOD_Leukemia	NIPSNAP1 →	+0.877	+0.417	<.001	.004	3	4
LARGE_INTESTINE	FBXO2 →	+1.624	+0.388	.001	.007	3	3
LARGE_INTESTINE	STMN3 →	+2.117	+0.565	.004	.005	3	3
LARGE_INTESTINE	TUBB3 →	+1.814	+0.524	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061003 vs GTF2H4 — BLOOD_Leukemia

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