Negative regulation of dendritic spine morphogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendritic spine morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A4, RHPN2, and ABI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendritic spine morphogenesis activity versus SLC1A4 in CCRCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC1A4 →	-0.270	-0.414	.001	.002	3	4
LSCC	RHPN2 →	+0.757	+0.792	.007	.002	3	3
GBM	ABI1 →	+0.520	+0.169	<.001	<.001	3	3
GBM	OPCML →	+1.256	+0.176	.005	<.001	3	3
GBM	GOLGA7B →	+0.942	+0.173	<.001	.002	2	3
UCEC	PLEKHA2 →	+0.374	+0.630	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061002 vs SLC1A4 — CCRCC

Explore this scatter interactively →