Positive regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DRB6, HLA-DQA2, and SNX8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine development activity versus HLA-DRB6 in UCEC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HLA-DRB6 →	-0.910	-0.479	.008	.007	3	4
CCRCC	HLA-DQA2 →	-1.683	-0.479	.002	.002	3	3
GBM	SNX8 →	-0.219	-0.632	.008	.002	3	3
BRCA	REEP5 →	+0.511	+0.278	.001	.002	3	3
BRCA	SLC43A3 →	-0.753	-0.347	.001	.001	3	3
BRCA	ARHGAP32 →	+0.889	+0.245	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060999 vs HLA-DRB6 — UCEC

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