Dendritic spine development

Across TCGA patient cohorts, RNA activity of the Dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BDKRB2, EHD4, and RNU6ATAC26P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic spine development activity versus BDKRB2 in COAD (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BDKRB2 →	+0.419	+0.419	.001	.003	3	3
OV	EHD4 →	+0.460	+0.338	<.001	.001	3	3
BRCA	RNU6ATAC26P →	+0.263	+0.611	.008	.003	3	3
BRCA	CARD14 →	+0.745	+0.523	<.001	<.001	3	2
COAD	LINC02779 →	+0.076	+0.393	.008	.002	3	2
COAD	FAM204BP →	-0.143	-0.278	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060996 vs BDKRB2 — COAD

Explore this scatter interactively →