Kidney morphogenesis

Across TCGA cell cohorts, RNA activity of the Kidney morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTKN, GADD45A, and MME, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTKN grouped by Kidney morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RTKN →	+1.248	+0.222	.001	.003	3	4
BONE	GADD45A →	-2.534	-1.671	<.001	<.001	3	4
BONE	MME →	-5.340	-1.562	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MGAT4B →	-1.291	-0.247	.004	.004	3	4
LARGE_INTESTINE	WDR88 →	-0.169	-0.213	.005	.002	3	3
CNS	TBL3 →	-0.529	-0.661	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTKN by Kidney morphogenesis activity — OVARY

Explore this box plot interactively →