Vasculogenesis involved in coronary vascular morphogenesis

Across TCGA patient cohorts, RNA activity of the Vasculogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHROOM4, BATF3, and NMRK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasculogenesis involved in coronary vascular morphogenesis activity versus SHROOM4 in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SHROOM4 →	+0.374	+0.146	<.001	<.001	3	4
GBM	BATF3 →	+0.598	+0.607	.003	.005	3	4
PDAC	NMRK1 →	-0.407	-0.151	.002	.002	3	3
PDAC	HIC1 →	+0.433	+0.131	.002	.001	3	3
HNSC	RBM17P3 →	+0.271	+0.115	.002	.006	3	3
CCRCC	RPL31P49 →	+0.271	+0.140	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060979 vs SHROOM4 — HNSC

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