Coronary vasculature development

Across TCGA cell cohorts, RNA activity of the Coronary vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAX9, GADD45B, and VAMP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAX9 grouped by Coronary vasculature development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PAX9 →	+0.511	+1.635	.005	<.001	3	4
BONE	GADD45B →	-3.479	-1.873	.001	<.001	3	4
BONE	VAMP5 →	-3.902	-1.529	.009	.004	3	4
BONE	ZNF169 →	+1.009	+1.810	.002	<.001	3	4
BONE	PIDD1 →	+1.175	+1.924	.005	<.001	3	4
BREAST	GDF9 →	+0.204	+0.555	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAX9 by Coronary vasculature development activity — KIDNEY

Explore this box plot interactively →