Endocardial cell differentiation

Across TCGA cell cohorts, RNA activity of the Endocardial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEMT, DNAJA3, and RNPS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEMT grouped by Endocardial cell differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PEMT →	+1.157	+1.053	.001	.005	3	4
URINARY_TRACT	DNAJA3 →	+1.327	+1.351	.002	.006	3	4
KIDNEY	RNPS1 →	+0.886	+1.361	<.001	.001	3	4
LUNG_NSCLC_LUAD	CNKSR3 →	+1.150	+0.895	.007	.002	3	4
LUNG_NSCLC_LUSC	PDCD2L →	+0.874	+1.178	.003	.007	3	3
LUNG_NSCLC_LUSC	UHRF2 →	-1.193	-1.214	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEMT by Endocardial cell differentiation activity — OESOPHAGUS

Explore this box plot interactively →