Endocardial cell differentiation

Across TCGA cell cohorts, RNA activity of the Endocardial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCND1, DOT1L, and CD37, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cell differentiation activity versus KCND1 in CNS (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KCND1 →	-1.047	-0.462	.004	<.001	3	1
CNS	DOT1L →	-0.907	-0.462	.007	<.001	3	1
CNS	CD37 →	-1.447	-0.462	.008	<.001	3	1
CNS	KLF1 →	-0.066	-0.506	<.001	.006	3	1
CNS	TFR2 →	-1.487	-0.462	.007	<.001	3	1
CNS	DCUN1D4 →	+0.837	+0.462	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060956 vs KCND1 — CNS

Explore this scatter interactively →