Cardiac vascular smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac vascular smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEURL1B, TUT4, and DCUN1D2-AS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac vascular smooth muscle cell differentiation activity versus NEURL1B in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NEURL1B →	+0.917	+0.373	.001	.005	3	5
BRCA	TUT4 →	+0.528	+0.726	<.001	<.001	3	4
BRCA	DCUN1D2-AS →	+0.565	+0.698	.004	.009	3	4
HNSC	ZNF555 →	+0.373	+0.483	.001	.004	3	4
CCRCC	ZNF510 →	+0.349	+0.804	.001	<.001	3	4
HNSC	TTC21B →	+0.479	+0.562	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060947 vs NEURL1B — OV

Explore this scatter interactively →