Cardiac fibroblast cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac fibroblast cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD4, B3GALT5, and C3orf14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac fibroblast cell differentiation activity versus PDCD4 in BRCA (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDCD4 →	+0.680	+0.081	<.001	<.001	3	4
COAD	B3GALT5 →	+0.831	+0.229	.005	.004	3	3
GBM	C3orf14 →	-0.603	-0.708	.004	.005	3	3
GBM	IRAIN →	+0.458	+0.802	.005	.002	3	3
BRCA	SLC25A35 →	+0.738	+0.121	<.001	<.001	3	3
BRCA	FRMPD3 →	+0.670	+0.085	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060935 vs PDCD4 — BRCA

Explore this scatter interactively →