Sinoatrial node cell differentiation

Across TCGA patient cohorts, RNA activity of the Sinoatrial node cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPM2, VCAN, and CNN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sinoatrial node cell differentiation activity versus TPM2 in CCRCC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TPM2 →	+0.718	+0.517	.002	.006	3	6
CCRCC	VCAN →	+0.698	+0.530	.003	.006	3	6
PDAC	CNN2 →	+0.537	+0.065	<.001	<.001	3	6
LSCC	ITGA11 →	+0.598	+0.072	<.001	.002	3	6
LSCC	VCL_S795 →	+0.533	+0.078	<.001	<.001	3	5
OV	PDLIM5 →	+0.820	+0.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060921 vs TPM2 — CCRCC

Explore this scatter interactively →