Sinoatrial node cell differentiation

Across TCGA cell cohorts, RNA activity of the Sinoatrial node cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCBLD2, STIMATE, and BLOC1S4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCBLD2 grouped by Sinoatrial node cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DCBLD2 →	-2.114	-1.810	.008	.001	3	4
URINARY_TRACT	STIMATE →	+0.960	+1.822	<.001	.003	3	3
STOMACH	BLOC1S4 →	-0.783	-1.535	<.001	<.001	3	3
BONE	PPP1R21 →	-0.819	-1.481	.003	<.001	3	3
LUNG_NSCLC_LUAD	TAF1D →	-0.551	-0.734	.008	.007	2	4
OVARY	CD59 →	-1.027	-0.864	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCBLD2 by Sinoatrial node cell differentiation activity — BONE

Explore this box plot interactively →