Cardiac pacemaker cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac pacemaker cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBX3_S707, FERMT2, and FLII_S856, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac pacemaker cell differentiation activity versus TBX3_S707 in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TBX3_S707 →	+0.647	+0.057	<.001	.003	3	5
BRCA	FERMT2 →	+0.499	+0.037	<.001	<.001	3	5
LSCC	FLII_S856 →	-0.466	-0.056	.004	.003	3	5
PDAC	MYLK_S1760 →	+0.743	+0.041	.002	.001	3	5
UCEC	EIF5B_S1168 →	-0.414	-0.120	<.001	<.001	3	5
BRCA	HMCN1 →	+0.478	+0.033	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060920 vs TBX3_S707 — LSCC

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