Cardiac pacemaker cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac pacemaker cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX3, SLPI, and OTUD7A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac pacemaker cell differentiation activity versus TBX3 in BRCA (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBX3 →	+1.523	+0.604	<.001	<.001	3	6
BRCA	SLPI →	-1.906	-0.517	.001	.001	3	5
PDAC	OTUD7A →	+0.180	+0.304	.002	.001	3	5
BRCA	SOX12 →	+0.569	+0.425	.002	.002	3	5
UCEC	LUC7L3 →	+0.520	+0.172	<.001	<.001	3	4
UCEC	FGF12 →	+0.516	+0.116	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060920 vs TBX3 — BRCA

Explore this scatter interactively →