Cardiac pacemaker cell differentiation

Across TCGA cell cohorts, RNA activity of the Cardiac pacemaker cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATXN1L, ZNF396, and HOXB13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATXN1L grouped by Cardiac pacemaker cell differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATXN1L →	+0.702	+1.282	.005	<.001	3	4
OVARY	ZNF396 →	-0.572	-1.290	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	HOXB13 →	-1.075	-1.366	.006	<.001	3	3
OVARY	NKX6-1 →	-0.758	-1.141	.002	.005	3	3
UPPER_AERODIGESTIVE_TRACT	VEPH1 →	-1.795	-1.052	.003	.003	3	3
UPPER_AERODIGESTIVE_TRACT	PRB3 →	-0.248	-1.321	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATXN1L by Cardiac pacemaker cell differentiation activity — LUNG_SCLC

Explore this box plot interactively →