Heart formation

Across TCGA patient cohorts, RNA activity of the Heart formation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S120, CEBPZ_S629, and DDX18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart formation activity versus TNS2_S120 in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNS2_S120 →	+0.469	+0.042	<.001	<.001	3	7
PDAC	CEBPZ_S629 →	-0.341	-0.075	.001	<.001	3	7
LUAD	DDX18 →	-0.300	-0.056	<.001	<.001	3	6
LUAD	EIF2S2 →	-0.190	-0.048	<.001	<.001	3	6
LSCC	BBS7 →	+0.266	+0.046	.003	.002	3	6
PDAC	FBLIM1_S222 →	+0.730	+0.084	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060914 vs TNS2_S120 — CCRCC

Explore this scatter interactively →