Heart formation

Across TCGA patient cohorts, RNA activity of the Heart formation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM5, KL, and BDH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart formation activity versus SMIM5 in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMIM5 →	-0.598	-0.681	<.001	<.001	3	4
CCRCC	KL →	+0.703	+0.315	.003	<.001	3	3
CCRCC	BDH2 →	+0.413	+0.325	.009	.004	3	3
CCRCC	EGOT →	+0.837	+0.285	<.001	.005	3	3
CCRCC	RCCD1-AS1 →	-0.147	-0.260	<.001	.004	3	3
CCRCC	LRP2 →	+2.555	+0.533	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060914 vs SMIM5 — LSCC

Explore this scatter interactively →