Heart formation

Across TCGA cell cohorts, RNA activity of the Heart formation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DPB1, COQ8A, and PDGFB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLA-DPB1 grouped by Heart formation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HLA-DPB1 →	-4.880	-1.169	<.001	<.001	3	4
CNS	COQ8A →	+1.069	+1.046	.003	.001	2	4
OVARY	PDGFB →	-1.983	-1.137	<.001	<.001	3	3
OVARY	NMRK1 →	-1.004	-1.092	.008	.002	3	3
OVARY	FURIN →	-1.281	-1.222	.001	<.001	3	3
URINARY_TRACT	DERA →	-0.724	-1.235	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLA-DPB1 by Heart formation activity — SKIN

Explore this box plot interactively →