Cardiac cell fate commitment

Across TCGA patient cohorts, RNA activity of the Cardiac cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC62_T158, SBNO2, and TP53BP1_S380, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac cell fate commitment activity versus SEC62_T158 in PDAC (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEC62_T158 →	-0.562	-0.042	<.001	.001	3	4
UCEC	SBNO2 →	-0.420	-0.118	.002	.001	3	3
HNSC	TP53BP1_S380 →	+0.443	+0.088	<.001	.001	3	3
HNSC	DSG2 →	+0.444	+0.087	.002	.004	3	3
HNSC	GLRX →	-0.285	-0.066	.003	<.001	3	3
OV	RBM14_S643 →	+0.852	+0.135	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060911 vs SEC62_T158 — PDAC

Explore this scatter interactively →