Cardiac cell fate commitment

Across TCGA cell cohorts, RNA activity of the Cardiac cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLS3, ALKBH2, and SLC27A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLS3 grouped by Cardiac cell fate commitment-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLS3 →	-2.153	-0.931	.007	.003	3	5
BONE	ALKBH2 →	+1.460	+1.759	.008	.001	3	5
OVARY	SLC27A2 →	-1.258	-1.433	<.001	<.001	3	5
STOMACH	PGRMC2 →	-1.013	-1.205	.002	.001	3	4
PANCREAS	APOL1 →	-2.793	-0.915	.003	.006	2	5
PANCREAS	TRAM1 →	-0.744	-0.811	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLS3 by Cardiac cell fate commitment activity — BLOOD_Leukemia

Explore this box plot interactively →