Cardiac cell fate commitment

Across TCGA cell cohorts, RNA activity of the Cardiac cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR1, CFAP73, and RHPN1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac cell fate commitment activity versus ACVR1 in BLOOD_Lymphoma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ACVR1 →	+1.941	+1.014	<.001	<.001	3	13
BLOOD_Lymphoma	CFAP73 →	-1.072	-0.826	<.001	<.001	3	7
LUNG_NSCLC_LUSC	RHPN1 →	-1.822	-1.217	.005	.002	2	8
BLOOD_Lymphoma	ANXA4 →	+1.866	+0.691	<.001	.003	3	6
BLOOD_Lymphoma	CCDC69 →	-2.732	-0.902	<.001	<.001	3	6
BREAST	C19orf81 →	-0.826	-1.089	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060911 vs ACVR1 — BLOOD_Lymphoma

Explore this scatter interactively →