Embryonic camera-type eye formation

Across TCGA cell cohorts, RNA activity of the Embryonic camera-type eye formation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, ALDH1A3, and SCNM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PROX1 grouped by Embryonic camera-type eye formation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROX1 →	-0.233	-1.392	<.001	<.001	3	6
BLOOD_Leukemia	ALDH1A3 →	-0.226	-1.578	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	SCNM1 →	+0.186	+1.182	.001	.007	3	5
UPPER_AERODIGESTIVE_TRACT	KCNA6 →	-0.148	-1.305	.001	<.001	3	5
BLOOD_Leukemia	KCNJ13 →	-0.227	-1.251	.001	<.001	3	4
PANCREAS	HOXB5 →	-0.149	-1.130	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PROX1 by Embryonic camera-type eye formation activity — BLOOD_Leukemia

Explore this box plot interactively →